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Yilong Zou, Boyi Gan, Li Jiang, and Yingying Yu for helpful discussion, and we apologize to our colleagues whose valuable contributions were not cited in this manuscript due entirely to space limitations

Pediatric dosing in the published trials titrated from 900 mg/day to 2,700 mg/day in older children

3,4 GLP-1RAs mimic the action of endogenous GLP-1, activating GLP-1R, thereby enhancing insulin secretion, inhibiting glucagon release, delaying gastric emptying, and reducing food intake through central appetite suppression