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4-hydroxy-2-nonenal induces apoptosis by activating ERK1/2 signaling and depleting intracellular glutathione in intestinal epithelial cells

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Weight loss itself may slow metabolic rate, particularly if muscle mass has been lost through undereating or reduced activity levels

When incorporated into advanced delivery systems like nanostructured lipid carriers (NLCs) or solid lipid nanoparticles (SLNs) , these natural agents may enhance the therapeutic efficacy of vitamin D analogs or corticosteroids by improving skin penetration , prolonging drug release , and reducing local and systemic toxicity (Bodnr et al