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Immune-modulating effects of GLP-1 receptor agonists are reported in several preclinical cancer studies, which may reflect direct action on immune cells or result from improved metabolic function

Soluble fibre is particularly effective: gut bacteria ferment it into short-chain fatty acids (SCFAs) like butyrate and propionate, which directly stimulate GLP-1-producing cells in the colon

The terms of the settlement are confidential and it remains unclear whether generic entry will happen once the main compound patent expires or later due the follow-on patents

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Methodological innovations such as standardised pharmacokinetic profiling, stratified analyses based on bioavailability, and the use of CONSORT and PRISMA guidline reporting would improve comparability and reproducibility

Stites DP & Terr AI (1991) Basic and clinical immunology