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The closest pipeline candidates are orforglipron, the first non-peptide oral GLP-1 from Eli Lilly, with an FDA decision anticipated in 2026, and retatrutide, a triple GLP-1/GIP/glucagon agonist in phase 3

In severe cases, such as those involving anaphylaxis, emergency medical intervention is required

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It consists of two identical single-chain subunits, each comprising 269 amino acid residues

Carnitine substitution resulted in an enhanced excretion of both, free carnitine and acylcarnitines, whereas acetylcarnitine accounts for 5065% of total acylcarnitines

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