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In patients with painful DPN, clinicians should offer tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, gabapentinoids and/or sodium channel blockers to reduce pain (Level B) and consider factors other than efficacy (Level B)

Glutamate Drugs Neuroplasticity Neuroplasticity indicates the brains ability to change over time and, more specifically, the ability of strengthening or weakening the synaptic signals between neurons in response to a variety of physiological stimuli such as behavioral, cognitive, and motor activities, as well as after pathological events such as painful or stressful conditions and neurological diseases (Lucassen et al., 2014

When prescribed and supervised by a BHRT doctor, BHRT is generally safe

The efficacy gap is enormous

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