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The introduction of GLP-1 agonists and SGLT-2 inhibitors offers a promising therapeutic option

It also improves insulin sensitivity, which makes it a solid match for the metabolic effects of semaglutide or tirzepatide

Wang, W., Ye, Z

, Omanovic Kolaric, T

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[11] In a randomized controlled trial (RCT) comparing liraglutide, glargine, glimepiride, and sitagliptin (all added to metformin) with a follow-up of five years, glargine and liraglutide were modestly more effective in achieving and maintaining target HbA1c, [20] with no difference in outcomes of microvascular and cardiovascular disease