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One prominent case included a teenager flying a Cessna into a skyscraper in Florida while on isotretinoin

The caveat is meaningful: people with pre-existing kidney disease should consult a physician before supplementing, because creatine metabolism does increase creatinine output, a standard kidney function marker that can skew lab results

By lessening inflammation, they help decrease pain and swelling after intense exercise

Benign prostatic hyperplasia could also lead to renal (kidney), urinary tract, and urinary bladder issues

PMC 3937312

Insulin Resistance: Unstable blood sugar levels can prevent the body from efficiently burning stored fat