REDEFINE Trial Headlines Trial REDEFINE 1 Phase 3 Duration 68 weeks Population (N) 3,417 adults with obesity or overweight + 1 comorbidity, without T2D Key Result 20.4% mean weight change vs 3.0% placebo (treatment-policy)
Garlic, onions, and cruciferous vegetables (broccoli, Brussels sprouts, kale) are rich in sulfur, which is essential for glutathione production
In individuals with certain genetic variants (HLA-DR), the immune system doesnt successfully clear the biotoxin signal, and inflammation continues even after exposures stopped
It primes the mast cell for activation as soon as the other half of the IgE binds to an antigen (on a pathogen/parasite/allergen)
The gut-brain axis connection means that gut healing reduces systemic inflammation reaching the brain, while direct neurotransmitter effects address mood regulation centrally
doi: 10.1016/j.cub.2020.09.068 12 SassettiEClausenMHLaraiaL