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Direct head-to-head trials are not yet available, but comparing across studies suggests retatrutide produces approximately 6-10 percentage points more weight loss than tirzepatide at equivalent treatment durations

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Women on HRT were also more likely to achieve the clinically meaningful thresholds of 5% and 10% total body weight loss

And employers and insurers that provide commercial coverage are wary of paying for these drugs in part because of the large number of patients that might use them

Statements Author contributions LB conceptualized the manuscript

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