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If nausea persists beyond three weeks or worsens, contact your PlexusDx provider to discuss dose adjustments or alternative formulations

Two main strategies have been used to modify the sequences of semaglutide and tirzepatide (red circles) and increase their bioavailability: 1) removal of the DPP-4 cleavage site, replacing alanine with an analogous molecule (-aminoisobutyric acid (Aib)), but not recognized by the enzyme

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