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Aberrant glycosylation has been observed to affect a number of oncogenes during tumorigenesis, including EGFR, where increased glycan branching results in increased residency time at the plasma membrane, thus increasing its active period (Lajoie et al, 2007)

FDA found no adequate clinical program that could define common adverse effects, rare serious effects, dose relationships, medication interactions, or risks in vulnerable patient groups

Magnetic resonance imaging and pathology studies have revealed that the greater neurological progression seen in males correlates with chronic immune activation and increased iron accumulation at the rims of chronic white matter lesions as well as more intensive whole brain and grey matter atrophy and axon loss

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