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Here, they identified metformin (an anti-diabetic drug) as a therapeutic activator of FOXO3 (86)

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Plasma concentrations of both IL-6 and TNF were unaffected by time, treatment, and the time treatment interaction (Figure 4D and E)

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All mice were from a C57BL/6 background and were group-housed and maintained in individual ventilated cages with standard bedding and enrichment in a temperature- and humidity-controlled room on a 12-h light:dark cycle (lights on 7:00) with AL access to food (standard diet, Scientific Animal Food Engineering, or 45% HFD) and water unless otherwise stated

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