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These changes stimulate vagal receptors in the oropharyngeal region, which transmit feeding signals to the stomach via the vagovagal reflex, initiating gastric accommodation

Park J, Choi J, Kim DD, Lee S, Lee B, Lee Y, et al

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And some of the barriers to adoption

doi:10.7314/apjcp.2014.15.9.4013

To maximise the cardiovascular benefits of GLP-1 RAs at a population level, strategies can be used to improve tolerability, such as patient counselling, gradual dose escalation and the use of long-acting formulations [27]