However, excessive accumulation of GSH precursors can overwhelm this reducing capacity, leading to reductive stress and aberrant mitochondrial H 2 O 2 production, a mechanism that is particularly pronounced in cancer cells characterized by elevated cysteine metabolism but limited antioxidant enzyme capacity 209
Western blot analysis To quantify the protein samples, tissue homogenates and cells were homogenized and quantified using a BCA kit (Beyotime, Shanghai, China)
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Berberine inhibits neuronal apoptosis by regulating autophagy-related proteins [Microtubule-associated protein 1A/1B-light chain 3 (LC3), Beclin-1, p62], and apoptosis regulatory proteins [caspase 3, caspase 8, caspase 9, poly ADP-ribose polymerase (PARP), and B-cell lymphoma 2 (Bcl-2)/Bcl-2 associated X (Bax)] (Zhang et al., 2016)
The introduction of tandem mass spectrometry (MS/MS) for the analysis of plasma acylcarnitine profile has greatly facilitated the identification of patients with defects in fatty acid -oxidation and has unquestionably been the most striking advance in newborn screening
