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Mechanism Difference: Tirzepatide (Zepbound/Mounjaro): Dual GIP/GLP-1 receptor agonist Semaglutide (Wegovy/Ozempic): GLP-1 receptor agonist only Published Clinical Trial Data (Separate Studies): Tirzepatide (SURMOUNT-1): 16.0% to 22.5% mean weight loss at 72 weeks depending on dose Semaglutide (STEP trials): Approximately 15% mean weight loss at 68 weeks These trials were conducted separately with different patient populations and protocols

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On Ozempic, Wegovy, or Mounjaro

Where the two receptors diverge is in their central nervous system activity

Kurowska-Stolarska M, Kewin P, Murphy G, Russo RC, Stolarski B, Garcia CC et al

When ROS production overwhelms endogenous antioxidant systems, it induces significant oxidative stress and steatosis (Ceni et al., 2014