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Free Radical Biology and Medicine 42.3 (2007): 371-384

How Ashwagandha Works in the Body Here's what ashwagandha does at a biological level: Regulates cortisol your primary stress hormone (1) Supports testosterone and thyroid hormone balance Modulates immune response via anti-inflammatory withanolides Enhances GABA receptor sensitivity for a calming effect Knowing this helps you understand why certain supplement combos amplify benefits while others create unwanted overlap or conflict

CXXC5 knockout mice showed accelerated hair regrowth compared to wild-type controls, validating that CXXC5 suppression drives the observed effects

Soluble NDCs are generally more susceptible to fermentation by gut microbiota than insoluble NDCs (56), and highly fermentable to be rapidly consumed by microbes (57)

eLife 4 , e11349 (2015)