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This is why many people who titrate up to 12.5mg or 15mg switch to a 15 mg/mL or 20 mg/mL concentration

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Physiological replacement of GLP-1 by exogenous administration had little effect, but this may underestimate the role of endogenous GLP-1 for insulin secretion, because intravenous administration bypasses important hepato-portal sensors for GLP-1 [63]