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371 Second, pharmacological reactivation of mutant p53 uses small molecules like APR-246, COTI-2, and arsenic trioxide (Table 7), which bind to mutant p53 and convert the protein to a p53 wild-type-like conformation, thus restoring wild-type DNA-binding properties

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Transition to maintenance with topical or lifestyle approaches

These include vitamin C, which helps to brighten the skin tone, and vitamin E, which helps to protect the skin from damage

Summary: CJC 1295, ipamorelin, and retatrutide are unapproved synthetic peptides with no licensed clinical use in the UK, each acting on distinct hormonal pathways related to growth hormone release or incretin signalling

However, proof of its positive effect on cardiovascular and renal outcomes in patients with T2D remains elusive