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Furthermore, in a Phase 1 randomized, double-blind, placebo-controlled clinical study (NCT04478708) in patients with obesity, adult obese subjects received either a single ascending dose (SAD) or multiple ascending doses (MAD) of AMG 133, compared with a placebo group

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165 The S-NO-AAT expresses a potent antimicrobial activity, inhibits cysteine proteases, and induces heme oxygenase-1 expression in hepatic ischemia-reperfusion injury in rats