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Compared to Supersomes, human S9 and hepatocyte-based assays showed slightly improved metabolite coverage with human liver microsomes providing the closest representation of human in vivo amide hydrolysis (differing from in vivo metabolism in the cases of acetanilide, paracetamol and lidocaine)

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They concluded that there was a significant difference among the three groups in terms of serum magnesium levels so persons during attacks and between migraine attacks had lower serum magnesium levels than healthy ones

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