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doi:10.1371/journal.pone.0215815 9

Journal of Physiology-Paris , 93 (6), 479485

Results found that undergoing a BFL dramatically decreased performance on the active avoidance test, the horizontal activity in the open field was disturbed, and there was diminished latency during the passive avoidance test

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These setbacks suggest that a more direct way of targeting the extracellular domain of TLR4, rather than its co-receptors or the intracellular TIR domain, may offer better efficacy and therapeutic potential