It is important to note that Nauck et al described the reduced incretin effect of GIP and not glucagon-like peptide 1 (GLP-1), because at that time GIP was the only incretin to have been identified and studied
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Moreover, dendritic cells and macrophages resident in visceral adipose depots exhibit an increased DPP4 expression in response to inflammation or in the obese state (28)
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If you have a personal or family history of medullary thyroid carcinoma, a history of pancreatitis, or severe gastroparesis, GLP-1 medications may genuinely not be safe for you
Most obesity medicine specialists recommend sequential monotherapy or waiting for robust clinical trial data before endorsing dual use
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