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The D-amino acid substitution preserves the spatial orientation of amino acid side chains needed for competitive binding to the FOXO4-p53 interaction surface, maintaining biological activity despite the non-natural backbone (PMID: 28340339)

Fertility and Sterility, 82 (2), S228

Miller, J

In small studies, most patients with chronic knee pain or chronic bladder pain reported major improvement after BPC157 treatment

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