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Tobaiqy (179) noted that clinicians must weigh the risks and benefits, monitor patients for adverse events, and conduct ongoing long-term safety assessments, especially regarding the cumulative effects and susceptibilities in specific populations

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Moreover, tocotrienols have been shown to exhibit superior antioxidant properties compared with tocopherols, potentially due to their ability to penetrate cell membranes more effectively and modulate various signaling pathways [111]

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That said, long-term use is not required for everyone

This is consistent with storage requirements for tirzepatide and semaglutide after reconstitution