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Emerging evidence demonstrates that GLP-1 receptors are expressed in Type II taste cells, where they modulate sweet sensitivity through the G-gustducin/TRPM5 pathway, and downregulate T1R2/T1R3 expression and ATP release (164, 165)

6 Discussion Recent evidence firmly establishes taste perception as a critical link between sensory biology and metabolic regulation, mediated by a complex neuroendocrine crosstalk within the gut-brain-taste axis