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Dopaminergic pathways are similarly affected, with reduced tyrosine hydroxylase activity leading to diminished dopamine in the basal ganglia and prefrontal cortex, manifesting as anhedonia, reduced motivation, and psychomotor retardation (73, 74)

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Because it targets both pathways, many people and clinical trials have shown better average weight loss and robust blood sugar reductions compared with single-target drugs

The findings could also push dementia drug research in new and fruitful directions

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