In three nested casecontrol studies from England and Wales, involving 440,089 patients with T2DM and without ASCVD treated with non-insulin glucose-lowering medication, combined SGLT2i and GLP-1RA therapy used for primary prevention was associated with 30% lower odds of MACE (defined as myocardial infarction/acute coronary syndrome, stroke/transient ischemic attack, and/or cardiovascular death) compared with other combination regimens (OR, 0.70
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Small mucocoele or benign lesion excisions heal over 710 days, with sutures (where used) removed at 57 days or dissolving on their own
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found that treatment with GLP-1RA leads to a 17% reduction in a broad composite kidney endpoint (development of new-onset macroalbuminuria, doubling of serum creatinine or 40% greater decline in estimated glomerular filtration rate (eGFR), progression to end-stage kidney disease, or kidney-related death), mainly as a result of a reduction in new-onset macroalbuminuria (15)
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