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Statistical analyses As Pearson correlation coefficients between the nine metabolite concentration values (three metabolites in three voxels) were substantial even after adjustment for potential confounders, we used principal component analysis (PCA) to identify latent metabolite variables, and extracted scores for each component (see Results and SA7 for details)

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The $300B patent cliff by 2030 (Evaluate, 2025) and GLP-1s $100B market amplify Hengruis stakes