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In vivo niches, SCs are present under hypoxic conditions and change in oxygen levels can induce oxidative stress, which can influence SC phenotype, proliferation, fate, pluripotency, etc., Therefore, in vitro culture conditions used to study MSCs should be maintained similar to their in vivo niches.[44] Combinational therapy using both platelet-rich plasma injections and stem-cell therapy PRP and SC therapy is continuously studied for their regenerative benefit in wound healing, sports medicine and chronic pain treatment

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