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A link between low testosterone and diabetes is evident considering that men with type 2 diabetes have lower testosterone levels than weight-matched nondiabetic control subjects [1]

Among the participants with pre-diabetes, 33% of those who discontinued their treatment early experienced normal blood sugar levels (defined by HbA1c level of 5.6 or lower), compared to 41% who discontinued their treatment late, and 67.9% who did not discontinue treatment

Genet 108 , 17101724 (2021)

That is not a way to treat the biology of a complex disease." These relatively new drugs, developed to mimic hunger hormones that we produce naturally, are also teaching scientists, including Jastreboff, about the mechanisms of the disease

For instance, older patients are susceptible to sarcopenia and fragility: Losing additional LBM due to pharmacotherapy is counterproductive to functional independence

Notably, no lethal dose could be determined in animals (no LD50 established)