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In animal models of heart failure induced by high-frequency pacing, ischaemia, and obesity, GLP-1RAs inhibit left ventricular remodelling and improve left ventricular contractility and diastolic function through anti-inflammatory effects, cardiomyocyte apoptosis inhibition, and glucose metabolism enhancement in cardiomyocytes [38,39,40]
Saudi J Gastroenterol 15:181187 Snchez-Fidalgo S, Villegas I, Rosillo M, Aparicio-Soto M, de la Lastra CA (2015) Dietary squalene supplementation improves DSS-induced acute colitis by downregulating p38 MAPK and NFkB signaling pathways
Future researchers should aim to delineate the regulatory mechanisms and dose-response relationships of the GLP-1R pathway under more refined experimental conditions, facilitating the development of precise immunotherapeutic strategies
Highlight the importance of increased fiber intake for improved blood glucose levels and other health benefits
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