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The efficacy of the combination in a spheroid model of NB provides confidence that it may translate to in vivo models

The regimen for vitamin B 12 therapy varies across countries and between individual practices

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Milk: Nil

Hydroxocobalamin may also be given intravenously in certain scenarios (for example, 5 g IV for acute cyanide poisoning antidote therapy), but such high-dose use is in emergency settings and distinct from routine deficiency treatment