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Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy

Epub 02008 Jul 00229

JP Richie Jr, S Nichenametla, W Neidig, et al

Rats possess thyroid C-cells that behave differently from human counterparts, and the doses used in animal models far exceeded typical human therapeutic ranges

[3] Initial dosing for moderate vasomotor symptoms typically ranges from 1 mg to 5 mg intramuscularly every three to four weeks, with some clinicians favoring a midpoint 2.5 mg monthly regimen and titrating upward or downward according to symptom relief and serum estradiol targets

10.1177/0022034517737025 3 AlkilzyM.TarabaihA.SantamariaR