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Oral B12 supplements require daily intake and have much lower bioavailability only about 1 to 2% is absorbed without intrinsic factor.
10.1006/exer.1999.0782 71
This makes it easier to measure
But its efficacy, honestly, depends almost entirely on correct reconstitution
First, the historical absence of a globally unified definition of rare diseases constrained our study scope to the top ten rare diseases with the highest R&D activity, which may not fully represent the broader spectrum of rare disease research
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