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The changes in biological metabolites (e.g., iron and lipids) support ferroptosis as a potential therapeutic strategy for RCC, while iron metabolism and ferroptosis regulation have been examined as anti-RCC agents in numerous studies, and various ferroptosis-related molecules have been shown to be related to the metastasis and prognosis of ccRCC

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Even though Pb + SL treatments raised G6PD activity more than the control group, the biggest increase compared to the Pb control was seen in the 6GPD and NRA enzymes (Table 8)

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