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MC4R integrates anorectic signals derived from alpha-melanocyte-stimulating hormone (MSH) and orexigenic signals generated by agouti-related peptide (AGRP) [3, 4]

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Treatment with the sodiumglucose cotransporter 2 inhibitor dapagliflozin was recently shown to reduce aortic stiffness, systolic BP and pulse pressure during exercise after just 24 weeks, and these changes were correlated with reductions in left ventricular filling pressures 25