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However, it should also be highlighted that low HbA1c was also associated with significantly increased COVID-19 mortality, which reinforces the clinical importance to avoid severe hypoglycemia

This single reaction sits at the intersection of two critical metabolic axes: The folate cycle axis: 5-MTHF is the methyl donor that MTR uses to regenerate methionine from homocysteine, simultaneously regenerating tetrahydrofolate (THF) that feeds back into one-carbon metabolism for nucleotide synthesis (thymidylate and purine biosynthesis)

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While we cannot disregard the possibility of some remaining effects of relaxation time differentials, we note that our results are metabolite-specific, while systematic between-group differences in relaxation times would likely impact all metabolite concentrations equally