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Side effects are mild and manageable: Bloating and GI discomfort are the most common complaints, and both can usually be resolved by splitting doses or increasing water intake

Tolu P, Masi F, Leggio B, et al

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Biocompatibility and effects on macrophage viability The cytotoxicity assay revealed that CM-EVs are highly biocompatible with RAW 264.7 macrophages