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Oswaldo Cruz , 90 , 235240

10.1016/S0140-6736(00)05183-7

A highly stabilized form of the amino acidL-carnitine

RosiqueCLebsirDBenatiaSGuigonPCaire-MaurisierFBenderitterMet al

In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years