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Mechanistically, melatonin acted independently of canonical melatonin receptors and instead reprogrammed ILC2 metabolism toward pentose phosphate pathway activity, enhancing NADPH generation and NRF2-dependent glutathione accumulation

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Our findings: Around 1 in 10 adults say theyre sensitive to gluten or wheat, yet true gluten-specific reactions were uncommon and typically mild FODMAPs and expectation effects explain most cases The symptoms are real - but the mechanisms are often gutbrain related, not gluten-driven A balanced approach works best: rule out coeliac disease, optimise diet quality, and consider short-term, dietitian-supervised trials rather than lifelong restriction Huge thanks to my co-authors and colleagues, including Jason Tye-Din, for their expertise and collaboration on this synthesis

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Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, Knig IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H, WTCCC and the Cardiogenics Consortium