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More channels means more pathways for the medication to influence your metabolism, but it also means more complexity and, potentially, more side effects

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200,201,202 Simultaneously, Akt promotes cell survival by phosphorylating and inhibiting a series of pro-apoptotic proteins, such as Bad and the FOXO family

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These data suggest that physicians may be preferentially selecting patients with type 1 diabetes thought to benefit most from either cardio-renal benefits of SGLT2i therapy or the weight reduction associated with GLP-1 RA, established in type 2 diabetes [17]