Other tiers you will see below: Moderate (one solid trial or a consistent real-world pattern), Emerging (early or contested signals), and Mechanistic Only (animal or lab work with no human data yet)
To put that in perspective: if your therapeutic dose is 500 mcg, you'd theoretically need 500,000 mcg (500 mg) to approach potentially toxic levels
EBioMedicine 20 , 137149 (2017)
Only one study in 24 individuals, the majority of which were healthy, reported that DSIP can reduce the depth of anesthesia, increase heart rate and even reduce the intensity of delta-waves in these subjects [28]
If you can diet and exercise during these wait months, then the results should be even better
Before starting any patient on a GLP-1 medication, I always explain how important it is to maintain their protein intake and keep up with resistance training