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Simultaneously, it activates glucagon receptors in hepatocytes and adipose tissue, driving energy expenditure by increasing thermogenesis and promoting fatty acid oxidation

Yang B, Yang C, Ren Q, Zhang JC, Chen QX, Shirayama Y, et al

Grapefruit contains compounds called furanocoumarins that significantly alter medication metabolism in the liver, potentially affecting how your body absorbs and uses semaglutide

This approval represented over a decade of clinical development, building on the drug's established safety profile from its original diabetes indication

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