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As a significant gut hormone, PYY is receiving attention in the treatment strategies of obesity and other metabolic disorders, particularly in combination therapies with other incretins

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The tripeptide HTL promotes glucose uptake through activation of adenosine monophosphate-activated protein kinase, whereas the oligopeptides FLSSTEAQQSY and TLVNPDGRDSY promote glucose uptake through activation of the PI3K/Akt pathway, which is facilitated in L6 myotubes (95)