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Butyrate acts blocks the IL-6/STAT3/IL-17 and TLR2-MyD88-NF-B pathways, and bidirectionally regulates cytokine secretion, Specifically, it upregulates anti-inflammatory factors such as IL-4 and IL-10 and downregulates pro-inflammatory factors such as CRP, IL-8, IL-12, and TNF- (66, 67, 91, 92)
Non-targeted lipidomic analysis revealed that levels of lysophosphatidylcholines (LysoPCs) and lysophosphatidylethanolamines (LysoPEs) were significantly increased in both GCH1-expressing and overexpressing cells following IKE treatment and contained PUFAs
10.1083/jcb.201007013 J
Why injection instead of oral supplements