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This may be attributed to the dimeric structure which hinders enzyme access to active sites, showcasing significant resistance to enzymatic degradation 49,55

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Bellmann-Weiler, R

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While the specific details of the ECD interface of Cagri-AMY 3 R could not be determined due to the low-resolution maps, these findings are indicative of substantial loss of RAMP3/CTR ECD interface interactions and considerable dynamic motions within the RAMP3 and CTR ECD protomers (Fig