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Each of its constituting monomers crosses the plasma-membrane six times and both the N and C-term face the cytoplasmic side, where they make up 70% of the receptors' entire volume (360)

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Comparative safety assessment demonstrated a statistically significant reduction in adverse reaction incidence with combination therapy (GLP-1 receptor agonists plus metformin) compared to monotherapy

The right column is where side effects and rapid weight loss can cause problems

Both medications can have side effects

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