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It acts as a selective antagonist of the sigma-1 receptor, a protein involved in various cellular processes, including neurotransmission and cell survival

For example, it has been found that polydatin promotes mitochondrial biogenesis and protects against mitochondrial oxidative stress via the activation of Sirtuin-1-PGC-1 pathway and Sirtuin-1-Nrf2-ARE pathway in kidney diseases (Huang et al., 2015

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Aloke C, Onisuru OO, Achilonu I (2024) Glutathione S-transferase: a versatile and dynamic enzyme

dEttorre, G

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