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Ling Du, [email protected] These authors have contributed equally to this work ORCID: Feng Liu, Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Considerations for cardiovascular and weight benefits discussed where appropriate

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Our findings support a role for Y1-R signaling in glucoregulation and highlight the therapeutic potential of simultaneous receptor targeting to achieve long-term benefits for millions of patients