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Mediation analysis supports a causal relationship between maternal hyperglycemia and placental DNA methylation variations at the leptin gene locus and cord blood leptin levels

Ethics declarations Ethics approval and consent to participate The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Independent Institutional Ethics Committee of IRCCS MultiMedica, Milan (protocol code 24/2012(153))

This product is not a cosmetic, drug, or food product

10.1038/nature00887 5 BistG.ElsheikhA.KimS.HuangR.Y.RuszajD.WooS.et al (2012)

Certain beneficial bacteria even produce metabolites that stimulate GLP-1 secretion

For these patients, microdosing offers a gentler approach to reduce the risk of side effects